Hydrochloric Acid → Hydrochloric Acid

HRID 2266284Notes

Reaction equation

HRID 2266284 reaction equation
[F:1][C:2]1[C:7]([C:8]2[CH:13]=[CH:12][CH:11]=[C:10]([CH3:14])[CH:9]=2)=[C:6]([CH:15]([C@@H:22]2[O:27][CH2:26][CH2:25][N:24](C(OC(C)(C)C)=O)[CH2:23]2)[CH2:16][CH2:17][CH2:18][CH2:19][O:20][CH3:21])[CH:5]=[CH:4][CH:3]=1.[ClH:35]>CO>[F:1][C:2]1[C:7]([C:8]2[CH:13]=[CH:12][CH:11]=[C:10]([CH3:14])[CH:9]=2)=[C:6]([CH:15]([C@@H:22]2[O:27][CH2:26][CH2:25][NH:24][CH2:23]2)[CH2:16][CH2:17][CH2:18][CH2:19][O:20][CH3:21])[CH:5]=[CH:4][CH:3]=1.[ClH:35]

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 59598520HCID 59598520, compound

Product 2

HCID 313Hydrochloric AcidHCID 59598501HCID 59598501, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Conditions

Temperature
50 °C

Procedure

(2S)-tert-butyl 2-(1-(6-fluoro-3′-methylbiphenyl-2-yl)-5-methoxypentyl)morpholine-4-carboxylate from Step 2 was dissolved in 1 M HCl in MeOH and stirred at 50° C. for 10 min, the solvent was removed under reduced pressure to give (2S)-2-(1-(6-fluoro-3′-methylbiphenyl-2-yl)-5-methoxypentyl)morpholine as its HCl salt in quantitative yield. MS m/z 494 (M+Na)+.

Workup

  1. customthe solvent was removed under reduced pressure

Sources & evidence

ORD record
ord-ee994b5940644235822886e4a599671f
Source dataset
uspto-grants-2010_12
Patent number
US07858624B2

Reaction notes

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