反应详情

温度

170 °C

A mixture of 3-amino-4-chlorophenol (2.2 g), 3-(4-chlorobenzyl)pentane-2,4-dione (3.4 g) and toluene-4-sulfonic acid (few crystals) was heated at 170° C. under nitrogen for 10 hours. The mixture was cooled to room temperature and purification by column chromatography on silica gel, eluting with a mixture of methanol and dichloromethane (1:19 by volume), followed by trituration with diethyl ether gave title compound as a pale brown solid, 0.41 g.

1. temperatureThe mixture was cooled to room temperature
2. custompurification by column chromatography on silica gel
3. washeluting with a mixture of methanol and dichloromethane (1:19 by volume)