反应详情

温度

140 °C

A mixture of 3-amino-4-chlorophenol (5.0 g), 3-(4-chlorophenylsulfanyl)pentane-2,4-dione (8.4 g), p-toluenesulfonic acid monohydrate (12 g) was heated at 140° C. for 6 hours. The mixture was cooled to room temperature and purified by column chromatography on silica gel, eluting with a mixture of dichloromethane and ethyl acetate (1:0 to 1:1 by volume) to afford title compound as a brown solid, 1.3 g.

1. temperatureThe mixture was cooled to room temperature
2. custompurified by column chromatography on silica gel
3. washeluting with a mixture of dichloromethane and ethyl acetate (1:0 to 1:1 by volume)