Ethyl Acetoacetate → 2-(2-chloro-4-methanesulfonylbenzyl)-3-oxobutyric Acid Ethyl Ester

HRID 2266506Notes

Reaction equation

Br[CH2:2][C:3]1[CH:8]=[CH:7][C:6]([S:9]([CH3:12])(=[O:11])=[O:10])=[CH:5][C:4]=1[Cl:13].[CH2:14]([O:16][C:17](=[O:22])[CH2:18][C:19](=[O:21])[CH3:20])[CH3:15]>>[CH2:14]([O:16][C:17](=[O:22])[CH:18]([CH2:2][C:3]1[CH:8]=[CH:7][C:6]([S:9]([CH3:12])(=[O:11])=[O:10])=[CH:5][C:4]=1[Cl:13])[C:19](=[O:21])[CH3:20])[CH3:15]

Participants

Reactant 2

HCID 8868Ethyl Acetoacetate

HCID 27610831-(Bromomethyl)-2-chloro-4-(methylsulfonyl)benzene

Product 1

HCID 687794542-(2-chloro-4-methanesulfonylbenzyl)-3-oxobutyric Acid Ethyl Ester

Procedure

The title compound was prepared by the method of Preparation 34a using 1-bromomethyl-2-chloro-4-methanesulfonylbenzene and 3-oxobutyric acid ethyl ester.

Sources & evidence

ORD record: ord-184d2dc3c84c463f837eaa79eeeebc69
Source dataset: uspto-grants-2010_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07858640B2

Reaction notes

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