HCID 3707209, compound → HCID 86631446, compound

HRID 2266552Notes

Reaction equation

HRID 2266552 reaction equation
C(O[C:4](=[O:18])[CH:5]([CH2:9][C:10]1[CH:15]=[CH:14][C:13]([Cl:16])=[CH:12][C:11]=1[Cl:17])[C:6](=[O:8])[CH3:7])C.[NH2:19][C:20]1[CH:21]=[C:22]([OH:27])[CH:23]=[CH:24][C:25]=1[F:26]>>[Cl:17][C:11]1[CH:12]=[C:13]([Cl:16])[CH:14]=[CH:15][C:10]=1[CH2:9][CH:5]([C:6](=[O:8])[CH3:7])[C:4]([NH:19][C:20]1[CH:21]=[C:22]([OH:27])[CH:23]=[CH:24][C:25]=1[F:26])=[O:18]

Participants

3

Reactant 2

HCID 3707209HCID 3707209, compoundHCID 135191803-Amino-4-fluorophenol

Product 1

HCID 86631446HCID 86631446, compound

Conditions

Temperature
120 °C

Procedure

A mixture of 2-(2,4-dichlorobenzyl)-3-oxobutyric acid ethyl ester (4.6 g) and 3-amino-4-fluorophenol (1.0 g) was heated by microwave irradiation at 120° C. for 20 minutes. The mixture was purified by column chromatography on silica gel, eluting with a mixture of ethyl acetate and pentane (1:19 to 1:1 by volume) to afford title compound, 0.67 g.

Workup

  1. customThe mixture was purified by column chromatography on silica gel
  2. washeluting with a mixture of ethyl acetate and pentane (1:19 to 1:1 by volume)

Sources & evidence

ORD record
ord-7b4f3e31e3554904a7ac2fac4dd0bd95
Source dataset
uspto-grants-2010_12
Patent number
US07858640B2

Reaction notes

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