Ethanol → N-(5-amino-2-fluorophenyl)acetamide(SALTDATA: 0.95HCl 0.8H2O)

HRID 2266559Notes

Reaction equation

HRID 2266559 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([N+:8]([O-])=O)=[CH:4][C:3]=1[NH2:11].[CH2:12]([OH:14])[CH3:13]>[Pd]>[NH2:8][C:5]1[CH:6]=[CH:7][C:2]([F:1])=[C:3]([NH:11][C:12](=[O:14])[CH3:13])[CH:4]=1

Participants

4

Reactant 2

HCID 702EthanolHCID 677852-Fluoro-5-nitroaniline

Product 1

HCID 12733834N-(5-amino-2-fluorophenyl)acetamide(SALTDATA: 0.95HCl 0.8H2O)

Reagents, catalysts & solvents 1

HCID 23938PalladiumCatalyst

Procedure

A mixture of 2-fluoro-5-nitrophenylamine (2.0 g), palladium, 10 wt. % on activated carbon (0.10 g) and ethanol (20 mL) were stirred at room temperature for 2 hours under an atmosphere of hydrogen. The mixture was filtered through hyflo, washing with ethanol and the solvent removed under reduced pressure to afford title compound as a white solid, 1.7 g.

Workup

  1. filtrationThe mixture was filtered through hyflo
  2. washwashing with ethanol
  3. customthe solvent removed under reduced pressure

Sources & evidence

ORD record
ord-4c067e12c1b242e9842467243ed7c935
Source dataset
uspto-grants-2010_12
Patent number
US07858640B2

Reaction notes

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