Butanethioic acid, 3-oxo-, S-(1,1-dimethylethyl) ester → 2-(4-chloro-2-fluorobenzyl)-3-oxothiobutyric acid S-tert-butyl Ester

HRID 2266571Notes

Reaction equation

HRID 2266571 reaction equation
Br[CH2:2][C:3]1[CH:8]=[CH:7][C:6]([Cl:9])=[CH:5][C:4]=1[F:10].[C:11]([S:15][C:16](=[O:21])[CH2:17][C:18](=[O:20])[CH3:19])([CH3:14])([CH3:13])[CH3:12]>>[C:11]([S:15][C:16](=[O:21])[CH:17]([CH2:2][C:3]1[CH:8]=[CH:7][C:6]([Cl:9])=[CH:5][C:4]=1[F:10])[C:18](=[O:20])[CH3:19])([CH3:14])([CH3:12])[CH3:13]

Participants

3

Reactant 2

HCID 140007Butanethioic acid, 3-oxo-, S-(1,1-dimethylethyl) esterHCID 27365514-Chloro-2-fluorobenzyl bromide

Product 1

HCID 866314512-(4-chloro-2-fluorobenzyl)-3-oxothiobutyric acid S-tert-butyl Ester

Procedure

The title compound was prepared by the method of Preparation 34a using 1-bromomethyl-4-chloro-2-fluorobenzene and 3-oxothiobutyric acid S-tert-butyl ester.

Sources & evidence

ORD record
ord-ac32139d5d2d4d0695f91b26a7887aba
Source dataset
uspto-grants-2010_12
Patent number
US07858640B2

Reaction notes

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