3-Amino-4-fluorophenol → 2-(2-chloro-4-fluorobenzyl)-N-(2-fluoro-5-hydroxyphenyl)-3-oxobutyramide

HRID 2266581Notes

Reaction equation

HRID 2266581 reaction equation
[NH2:1][C:2]1[CH:3]=[C:4]([OH:9])[CH:5]=[CH:6][C:7]=1[F:8].C(S[C:15](=[O:29])[CH:16]([CH2:20][C:21]1[CH:26]=[CH:25][C:24]([F:27])=[CH:23][C:22]=1[Cl:28])[C:17](=[O:19])[CH3:18])(C)(C)C>>[Cl:28][C:22]1[CH:23]=[C:24]([F:27])[CH:25]=[CH:26][C:21]=1[CH2:20][CH:16]([C:17](=[O:19])[CH3:18])[C:15]([NH:1][C:2]1[CH:3]=[C:4]([OH:9])[CH:5]=[CH:6][C:7]=1[F:8])=[O:29]

Participants

3

Reactant 2

HCID 135191803-Amino-4-fluorophenolHCID 86631454HCID 86631454, compound

Product 1

HCID 866314552-(2-chloro-4-fluorobenzyl)-N-(2-fluoro-5-hydroxyphenyl)-3-oxobutyramide

Procedure

The title compound was prepared by the method of Preparation 34b using 3-amino-4-fluorophenol and 2-(2-chloro-4-fluorobenzyl)-3-oxothiobutyric acid S-tert-butyl ester.

Sources & evidence

ORD record
ord-82fd6ba868094685b2e4c4b97ec7b464
Source dataset
uspto-grants-2010_12
Patent number
US07858640B2

Reaction notes

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