(3-Amino-4-fluorophenoxy)acetic acid methyl ester → {3-[2-chloro-4-(pyrrolidine-1-carbonyl)benzyl]-2-ethyl-8-fluoro-4-oxo-1,4-dihydroquinolin-5-yloxy}acetic Acid Methyl Ester

HRID 2266621Notes

Reaction equation

HRID 2266621 reaction equation
C([O:3][C:4](=O)[CH:5]([CH2:10][C:11]1[CH:16]=[CH:15][C:14]([C:17]([N:19]2[CH2:23][CH2:22][CH2:21][CH2:20]2)=[O:18])=[CH:13][C:12]=1[Cl:24])[C:6](=O)[CH2:7][CH3:8])C.[CH3:26][O:27][C:28](=[O:39])[CH2:29][O:30][C:31]1[CH:36]=[CH:35][C:34]([F:37])=[C:33]([NH2:38])[CH:32]=1>>[CH3:26][O:27][C:28](=[O:39])[CH2:29][O:30][C:31]1[CH:36]=[CH:35][C:34]([F:37])=[C:33]2[C:32]=1[C:4](=[O:3])[C:5]([CH2:10][C:11]1[CH:16]=[CH:15][C:14]([C:17]([N:19]3[CH2:23][CH2:22][CH2:21][CH2:20]3)=[O:18])=[CH:13][C:12]=1[Cl:24])=[C:6]([CH2:7][CH3:8])[NH:38]2

Participants

3

Reactant 2

HCID 66717607(3-Amino-4-fluorophenoxy)acetic acid methyl esterHCID 687846752-[2-chloro-4-(pyrrolidine-1-carbonyl)benzyl]-3-oxopentanoic Acid Ethyl Ester

Product 1

HCID 68783901{3-[2-chloro-4-(pyrrolidine-1-carbonyl)benzyl]-2-ethyl-8-fluoro-4-oxo-1,4-dihydroquinolin-5-yloxy}acetic Acid Methyl Ester

Procedure

The title compound was prepared by the method of Preparation 65c using 2-[2-chloro-4-(pyrrolidine-1-carbonyl)benzyl]-3-oxopentanoic acid ethyl ester and (3-amino-4-fluorophenoxy)acetic acid methyl ester.

Sources & evidence

ORD record
ord-c3cb77b2bdab4992ae5d8ea62fef2596
Source dataset
uspto-grants-2010_12
Patent number
US07858640B2

Reaction notes

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