(S)-2-(3-amino-4-fluorophenoxy)propionic acid methyl ester → (S)-2-[3-(2,4-dichlorobenzyl)-2-ethyl-8-fluoro-4-oxo-1,4-dihydroquinolin-5-yloxy]propionic Acid Methyl Ester

HRID 2266626Notes

Reaction equation

HRID 2266626 reaction equation
[CH3:1][O:2][C:3](=[O:15])[C@@H:4]([O:6][C:7]1[CH:12]=[CH:11][C:10]([F:13])=[C:9]([NH2:14])[CH:8]=1)[CH3:5].C[O:17][C:18](=O)[CH:19]([CH2:24][C:25]1[CH:30]=[CH:29][C:28]([Cl:31])=[CH:27][C:26]=1[Cl:32])[C:20](=O)[CH2:21][CH3:22]>>[CH3:1][O:2][C:3](=[O:15])[C@@H:4]([O:6][C:7]1[CH:12]=[CH:11][C:10]([F:13])=[C:9]2[C:8]=1[C:18](=[O:17])[C:19]([CH2:24][C:25]1[CH:30]=[CH:29][C:28]([Cl:31])=[CH:27][C:26]=1[Cl:32])=[C:20]([CH2:21][CH3:22])[NH:14]2)[CH3:5]

Participants

3

Reactant 2

HCID 66717596(S)-2-(3-amino-4-fluorophenoxy)propionic acid methyl esterHCID 687814912-(2,4-dichlorobenzyl)-3-oxopentanoic Acid Methyl Ester

Product 1

HCID 68782222(S)-2-[3-(2,4-dichlorobenzyl)-2-ethyl-8-fluoro-4-oxo-1,4-dihydroquinolin-5-yloxy]propionic Acid Methyl Ester

Procedure

The title compounds were prepared by the method of Preparation 65c using (S)-2-(3-amino-4-fluorophenoxy)propionic acid methyl ester and 2-(2,4-dichlorobenzyl)-3-oxopentanoic acid methyl ester.

Sources & evidence

ORD record
ord-8671ef799d2740ed9efa8d65084c45d2
Source dataset
uspto-grants-2010_12
Patent number
US07858640B2

Reaction notes

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