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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2266626Generated: October 25, 2026

(S)-2-(3-amino-4-fluorophenoxy)propionic acid methyl ester → (S)-2-[3-(2,4-dichlorobenzyl)-2-ethyl-8-fluoro-4-oxo-1,4-dihydroquinolin-5-yloxy]propionic Acid Methyl Ester

https://huagongshe.com/reaction/2266626

Reaction equation

Participants

RoleNameHCIDCharge
Reactant(S)-2-(3-amino-4-fluorophenoxy)propionic acid methyl esterHCID 66717596—
Reactant2-(2,4-dichlorobenzyl)-3-oxopentanoic Acid Methyl EsterHCID 68781491—
Product(S)-2-[3-(2,4-dichlorobenzyl)-2-ethyl-8-fluoro-4-oxo-1,4-dihydroquinolin-5-yloxy]propionic Acid Methyl EsterHCID 68782222—

Reaction Steps

The title compounds were prepared by the method of Preparation 65c using (S)-2-(3-amino-4-fluorophenoxy)propionic acid methyl ester and 2-(2,4-dichlorobenzyl)-3-oxopentanoic acid methyl ester.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07858640B2
Source datasetuspto-grants-2010_12
ORD IDord-8671ef799d2740ed9efa8d65084c45d2
Source noteuspto-grants-2010_12