反应详情

温度

100 °C

A mixture of [3-(4-chlorobenzyl)-4,7-dimethylquinolin-5-yloxy]acetic acid methyl ester (1.8 g), tetrahydrofuran and potassium trimethylsilanolate (0.19 g) was heated at 100° C. in a microwave reactor for 5 minutes. The mixture was concentrated under reduced pressure, diluted with water and acidified by the addition of concentrated hydrochloric acid. The resulting precipitate was collected by filtration and purified by preparative reverse-phase HPLC, using a gradient over 30 minutes of acetonitrile in water (35% to 95% organic modifier) to afford title compound, 0.015 g.

1. concentrationThe mixture was concentrated under reduced pressure
2. additiondiluted with water
3. additionacidified by the addition of concentrated hydrochloric acid
4. filtrationThe resulting precipitate was collected by filtration
5. custompurified by preparative reverse-phase HPLC
6. customover 30 minutes