Hydrochloric Acid → HCID 68782253, compound

HRID 2266636Notes

Reaction equation

HRID 2266636 reaction equation
[CH3:1][O:2][C:3](=[O:27])[CH2:4][O:5][C:6]1[CH:15]=[CH:14][C:13](Cl)=[C:12]2[C:7]=1[C:8](Cl)=[C:9]([CH2:18][C:19]1[CH:24]=[CH:23][C:22]([Cl:25])=[CH:21][CH:20]=1)[C:10]([CH3:17])=[N:11]2.Cl>[Pd].C(O)C>[CH3:1][O:2][C:3](=[O:27])[CH2:4][O:5][C:6]1[CH:15]=[CH:14][CH:13]=[C:12]2[C:7]=1[CH:8]=[C:9]([CH2:18][C:19]1[CH:20]=[CH:21][C:22]([Cl:25])=[CH:23][CH:24]=1)[C:10]([CH3:17])=[N:11]2

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 68780328HCID 68780328, compound

Product 1

HCID 68782253HCID 68782253, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

A mixture of [4,8-dichloro-3-(4-chlorobenzyl)-2-methylquinolin-5-yloxy]acetic acid methyl ester (0.13 g), palladium (5 wt. % on activated carbon, 0.010 g), ethanol (5.0 mL) and 1.0 M aqueous hydrochloric acid (1.0 mL) was stirred at room temperature for 17 hours under an atmosphere of hydrogen. The mixture was filtered through hyflo, washing with ethanol and water and the solvent removed under reduced pressure to afford title compound, 0.11 g.

Workup

  1. filtrationThe mixture was filtered through hyflo
  2. washwashing with ethanol and water
  3. customthe solvent removed under reduced pressure

Sources & evidence

ORD record
ord-e7323e666f834045925bce911de9b04a
Source dataset
uspto-grants-2010_12
Patent number
US07858640B2

Reaction notes

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