Pyridine → 1-Chloroethyl 1-methylethyl carbonate

Temperature

0 °C

0.66 g of isopropanol was added to 1.43 g of 1-chloroethyl chloroformate, and the solution was cooled to 0° C. in an ice-water bath. The mixture of 0.84 g of pyridine and 10 ml ethyl ether was added dropwise into the solution. The solution was reacted for 1 hour at that temperature, following 4 hours at room temperature. The reaction was stopped and the mixture was filtered, and the filtrate was washed respectively with 10% hydrochloric acid and water once. The organic phase was dried and concentrated to give 1.461 g of a light yellow liquid 1-chloroethyl isopropyl carbonate with a yield of 87.7%. The crude was directly used in the next reaction without purification.

1. additionwas added dropwise into the solution
2. customThe solution was reacted for 1 hour at that temperature
3. filtrationthe mixture was filtered
4. washthe filtrate was washed respectively with 10% hydrochloric acid and water once
5. customThe organic phase was dried
6. concentrationconcentrated

ORD record

ord-95fc644ac2074a039db5959f556f3e6a

Source dataset

uspto-grants-2010_12

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US07858651B2