HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2266956Generated: November 3, 2026
Water → Isobutyl 4-(4-(2-(difluoromethyl)phenyl)pyrimidin-2-yl)piperazine-1-carboxylate
https://huagongshe.com/reaction/2266956
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | Isobutyl 1-(4-chloropyrimidin-2-yl)piperazine-4-carboxylate | HCID 58857071 | — |
| Reactant | 2-[2-(Difluoromethyl)phenyl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane | HCID 59264588 | — |
| Catalyst | HCID 178418397 | HCID 178418397 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | Isobutyl 4-(4-(2-(difluoromethyl)phenyl)pyrimidin-2-yl)piperazine-1-carboxylate | HCID 16097306 | — |
Reaction Steps
To a solution of the isobutyl 4-(4-chloropyrimidin-2-yl)piperazine-1-carboxylate 8a and 2-(2-(difluoromethyl)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane 11a (1.2 eq) in acetonitrile was added Pd(PPh3)4 (0.10 eq), K2CO3 (2 eq) and water. The vial was sealed and heated by microwave irradiation at 120° C. for 15 minutes. The solvent was evaporated and the residue was dissolved in DMF and purified by reverse phase HPLC (using 10%-99% CH3CN (0.035% TFA)/H2O (0.05% TFA) to give 24. m/z 391.1 (M+1), r.t: 3.59 (10%-99% CH3CN (0.035% TFA)/H2O (0.05% TFA)).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07858786B2 |
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| Source dataset | uspto-grants-2010_12 |
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| ORD ID | ord-6d0acf4e72944227b563d2a4c7a3fd83 |
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| Source note | uspto-grants-2010_12 |
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