5-Bromopyridine-2-carbonitrile → 5-(4-(Hydroxymethyl)phenylthio)picolinonitrile

HRID 2267053노트

반응식

HRID 2267053 반응식
[SH:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][OH:9])=[CH:4][CH:3]=1.Br[C:11]1[CH:12]=[CH:13][C:14]([C:17]#[N:18])=[N:15][CH:16]=1>>[OH:9][CH2:8][C:5]1[CH:6]=[CH:7][C:2]([S:1][C:11]2[CH:12]=[CH:13][C:14]([C:17]#[N:18])=[N:15][CH:16]=2)=[CH:3][CH:4]=1

참가 물질

3

반응물 2

HCID 8171545-Bromopyridine-2-carbonitrileHCID 4677905(4-Sulfanylphenyl)methanol

생성물 1

HCID 685392925-(4-(Hydroxymethyl)phenylthio)picolinonitrile수율 28.4%

실험 절차

Using the method of Preparation 155 using (4-mercaptophenyl)methanol (10.0 g, 71.3 mmol) and 5-bromopicolinonitrile (13.0 g, 71.3 mmol) affords the title compound (4.90 g, 28%).): 243 (M+H, 100%).

출처 및 근거

ORD 기록
ord-6070c006cad640c9b36bf0edf7932479
출처 데이터셋
uspto-grants-2010_12
특허 번호
US07858646B2

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