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1-(2,4-Dihydroxy-3-methylphenyl)ethan-1-one → 2-(3-((4-Acetyl-3-hydroxy-2-methylphenoxy)methyl)phenylthio) isonicotinonitrile
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 1-(2,4-Dihydroxy-3-methylphenyl)ethan-1-one | HCID 592139 | — |
| 反応物 | 2-{[3-(Hydroxymethyl)phenyl]sulfanyl}pyridine-4-carbonitrile | HCID 57355460 | — |
| 生成物 | 2-(3-((4-Acetyl-3-hydroxy-2-methylphenoxy)methyl)phenylthio) isonicotinonitrile | HCID 68537769 | 52% |
反応手順
Using the method of Preparation 166 using 2-(3-(hydroxymethyl)phenylthio) isonicotinonitrile (1.46 g, 6.02 mmol) and 1-(2,4-dihydroxy-3-methylphenyl)ethanone (1.00 g, 6.02 mmol) affords the title compound (1.22 g, 52%). MS (APCI-neg) m/z (rel intensity): 389 (M−H, 100%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07858646B2 |
| 出典データセット | uspto-grants-2010_12 |
| ORD ID | ord-ebc5f64e2797474d8bf03e3017a24606 |
| 出典メモ | uspto-grants-2010_12 |