HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-(3-Ethyl-2,4-dihydroxyphenyl)ethanone → 6-(3-((4-Acetyl-2-ethyl-3-hydroxyphenoxy)methyl)phenylthio) isonicotinonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-(3-Ethyl-2,4-dihydroxyphenyl)ethanone | HCID 21287021 | — |
| Reactant | 2-{[3-(Hydroxymethyl)phenyl]sulfanyl}pyridine-4-carbonitrile | HCID 57355460 | — |
| Product | 6-(3-((4-Acetyl-2-ethyl-3-hydroxyphenoxy)methyl)phenylthio) isonicotinonitrile | HCID 68535845 | 80% |
Reaction Steps
Using the method of Preparation 166 using 6-(3-(hydroxymethyl)phenylthio) isonicotinonitrile (1.35 g, 5.56 mmol) and 1-(3-ethyl-2,4-dihydroxyphenyl)ethanone (1.00 g, 5.56 mmol) affords the title compound (1.80 g, 80%). MS (APCI-neg) m/z (rel intensity): 403 (M−H, 100%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07858646B2 |
| Source dataset | uspto-grants-2010_12 |
| ORD ID | ord-95babea68fc14ad389e2aff3300d1fa1 |
| Source note | uspto-grants-2010_12 |