Hydrogen chloride-ethyl acetate → HCID 68428295, compound

HRID 2267165Notes

Reaction equation

HRID 2267165 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[N:8]1[CH:12]=[C:11]([C:13]2[CH2:14][CH2:15][N:16](C(OC(C)(C)C)=O)[CH2:17][CH:18]=2)[N:10]=[N:9]1.[ClH:26].C(OCC)(=O)C>>[ClH:26].[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[N:8]1[CH:12]=[C:11]([C:13]2[CH2:14][CH2:15][NH:16][CH2:17][CH:18]=2)[N:10]=[N:9]1

Participants

3

Reactant 2

HCID 21866389Hydrogen chloride-ethyl acetateHCID 44588385HCID 44588385, compound

Product 1

HCID 68428295HCID 68428295, compound

Procedure

tert-Butyl 4-[1-(2-fluorophenyl)-1H-[1,2,3]triazol-4-yl]-1,2,3,6-tetrahydropyridine-1-carboxylate (70 mg) prepared in Example 5 was dissolved in 2.0 ml of 4N hydrochloric acid/ethyl acetate solution followed by stirring at room temperature for 30 minutes. The solvent was evaporated in vacuo to give the title compound as a brown crude product.

Workup

  1. customThe solvent was evaporated in vacuo

Sources & evidence

ORD record
ord-3643f6c821a8416b8860efc85a9782c3
Source dataset
uspto-grants-2010_12
Patent number
US07858800B2

Reaction notes

Loading…