Triethylamine → HCID 87452494, compound

HRID 2267175Notes

Reaction equation

HRID 2267175 reaction equation
Cl.[Cl:2][C:3]1[C:8]([N:9]2[C:13](C)=[C:12]([C:15]3[CH2:16][CH2:17][NH:18][CH2:19][CH:20]=3)[N:11]=[N:10]2)=[CH:7][CH:6]=[CH:5][N:4]=1.C(N(CC)CC)C.Cl[C:29]([O:31][CH2:32][CH2:33][O:34][CH3:35])=[O:30]>ClCCl>[Cl:2][C:3]1[C:8]([N:9]2[CH:13]=[C:12]([C:15]3[CH2:16][CH2:17][N:18]([C:29]([O:31][CH2:32][CH2:33][O:34][CH3:35])=[O:30])[CH2:19][CH:20]=3)[N:11]=[N:10]2)=[CH:7][CH:6]=[CH:5][N:4]=1

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 694002-Methoxyethyl chloroformateHCID 87452644HCID 87452644, compound

Product 1

HCID 87452494HCID 87452494, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

2-Chloro-3-[5-methyl-4-(1,2,3,6-tetrahydropyridin-4-yl)-[1,2,3]triazol-1-yl]-pyridine hydrochloride (3.0 mg) prepared in Example 42-1 was dissolved in 1.0 ml of dichloromethane and 0.02 ml of triethylamine and 0.02 ml of 2-methoxyethyl chloroformate were added thereto followed by stirring at room temperature for 10 minutes. The solvent was evaporated in vacuo and the residue was separated and purified by a thin-layer chromatography (ethyl acetate) to give 1.36 mg of the title compound as a white solid.

Workup

  1. customThe solvent was evaporated in vacuo
  2. customthe residue was separated
  3. custompurified by a thin-layer chromatography (ethyl acetate)

Sources & evidence

ORD record
ord-c285abec5a214850a00a4be4d2733f6d
Source dataset
uspto-grants-2010_12
Patent number
US07858800B2

Reaction notes

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