HCID 44588425, compound → HCID 68430348, compound

HRID 2267176Notes

Reaction equation

HRID 2267176 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[CH:12]=[C:11]([C:13]3[CH2:14][CH2:15][N:16](C(OC(C)(C)C)=O)[CH2:17][CH:18]=3)[N:10]=[N:9]2)=[CH:4][CH:3]=1>Cl.C(OCC)(=O)C>[F:1][C:2]1[CH:3]=[CH:4][C:5]([N:8]2[CH:12]=[C:11]([C:13]3[CH2:14][CH2:15][NH:16][CH2:17][CH:18]=3)[N:10]=[N:9]2)=[CH:6][CH:7]=1

Participants

3

Reactant 1

HCID 44588425HCID 44588425, compound

Product 1

HCID 68430348HCID 68430348, compound

Reagents, catalysts & solvents 1

HCID 21866389Hydrogen chloride-ethyl acetateSolvent

Procedure

tert-Butyl 4-[1-(4-fluorophenyl)-1H-[1,2,3]triazol-4-yl]-1,2,3,6-tetrahydropyridine-1-carboxylate (50 mg) prepared in Example 13 was dissolved in 4.0 ml of 4N-hydrochloric acid/ethyl acetate, the mixture was stirred for one night and, after evaporation of the solvent in vacuo, a saturate sodium hydrogen carbonate and chloroform were added. The organic layer was dried over sodium sulfate and the solvent was evaporated in vacuo to give the title compound as a mixture.

Workup

  1. customafter evaporation of the solvent in vacuo
  2. additiona saturate sodium hydrogen carbonate and chloroform were added
  3. dry with materialThe organic layer was dried over sodium sulfate
  4. customthe solvent was evaporated in vacuo

Sources & evidence

ORD record
ord-74cbde3c79424e11855f0f801bacdc01
Source dataset
uspto-grants-2010_12
Patent number
US07858800B2

Reaction notes

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