Triethylamine → HCID 58945844, compound

HRID 2267178Notes

Reaction equation

HRID 2267178 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[N:8]1[C:12]([CH3:13])=[C:11]([N:14]2[CH2:19][CH2:18][NH:17][CH2:16][C:15]2=[O:20])[N:10]=[N:9]1.[C:21]([N:25]=[C:26]=[O:27])([CH3:24])([CH3:23])[CH3:22].C(N(CC)CC)C>C(Cl)(Cl)Cl>[C:21]([NH:25][C:26]([N:17]1[CH2:18][CH2:19][N:14]([C:11]2[N:10]=[N:9][N:8]([C:3]3[CH:4]=[CH:5][CH:6]=[CH:7][C:2]=3[Cl:1])[C:12]=2[CH3:13])[C:15](=[O:20])[CH2:16]1)=[O:27])([CH3:24])([CH3:23])[CH3:22]

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 62412tert-Butyl isocyanateHCID 68429818HCID 68429818, compound

Product 1

HCID 58945844HCID 58945844, compound

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

In a nitrogen atmosphere, 4-[1-(2-chlorophenyl)-5-methyl-1H-[1,2,3]triazol-4-yl]-3-oxopiperazine prepared in 1) of Example 51 was dissolved in 1 ml of chloroform and 0.05 ml of tert-butyl isocyanate and 0.1 ml of triethylamine were added thereto followed by stirring at room temperature for 2 hours. After the solvent was evaporated in vacuo, the resulting residue was purified by a preparative thin-layer silica gel chromatography (chloroform:methanol=9:1) to give 5 mg of the title compound as a white solid.

Workup

  1. customAfter the solvent was evaporated in vacuo
  2. customthe resulting residue was purified by a preparative thin-layer silica gel chromatography (chloroform:methanol=9:1)

Sources & evidence

ORD record
ord-110312a704b44abf93e6b817a2c205e8
Source dataset
uspto-grants-2010_12
Patent number
US07858800B2

Reaction notes

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