HCID 58945859, compound → 4-(5-methyl-1-phenyl-1H-[1,2,3]-triazol-4-yl)-3-oxopiperazine

HRID 2267179Notes

Reaction equation

HRID 2267179 reaction equation
[CH3:1][C:2]1[N:6]([C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=2)[N:5]=[N:4][C:3]=1[N:13]1[CH2:18][CH2:17][N:16](C(OC(C)(C)C)=O)[CH2:15][C:14]1=[O:26]>Cl.O1CCOCC1>[CH3:1][C:2]1[N:6]([C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=2)[N:5]=[N:4][C:3]=1[N:13]1[CH2:18][CH2:17][NH:16][CH2:15][C:14]1=[O:26]

Participants

3

Reactant 1

HCID 58945859HCID 58945859, compound

Product 1

HCID 684310614-(5-methyl-1-phenyl-1H-[1,2,3]-triazol-4-yl)-3-oxopiperazine

Reagents, catalysts & solvents 1

HCID 204431481,4-Dioxane hydrochlorideSolvent

Procedure

4N hydrochloric acid/dioxane solution (10 ml) was added to tert-butyl 4-(5-methyl-1-phenyl-1H-[1,2,3]triazol-4-yl)-3-oxopiperazine-1-carboxylate prepared in Example 29 followed by stirring at room temperature for 3 hours and the solvent was evaporated in vacuo to give 60 mg of the title compound as a white solid.

Workup

  1. customthe solvent was evaporated in vacuo

Sources & evidence

ORD record
ord-fa1d7e35feb144059cfd7cab5ef9477f
Source dataset
uspto-grants-2010_12
Patent number
US07858800B2

Reaction notes

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