Hydrochloric Acid → HCID 9933004, compound

Participants

Reaction Conditions

Reaction Steps

The mixture of nebivolol (48.5 gm) and methanol (950 ml) was refluxed for 30 minutes and then subjected to carbon treatment. The resulting mass was cooled to 0-10° C., hydrochloric acid (6.5 ml) was slowly added during 30 minutes and then stirred for 4 hours at 0-10C. Filtered the material, washed with 50 ml of methanol and dried at 50-60° C. to give 27.5 gm of Nebivolol hydrochloride salt (HPLC purity: 99.5%).

Provenance & Evidence