反应详情

温度

5 °C

The mixture of nebivolol (48.5 gm) and methanol (950 ml) was refluxed for 30 minutes and then subjected to carbon treatment. The resulting mass was cooled to 0-10° C., hydrochloric acid (6.5 ml) was slowly added during 30 minutes and then stirred for 4 hours at 0-10C. Filtered the material, washed with 50 ml of methanol and dried at 50-60° C. to give 27.5 gm of Nebivolol hydrochloride salt (HPLC purity: 99.5%).

1. temperaturewas refluxed for 30 minutes
2. filtrationFiltered the material
3. washwashed with 50 ml of methanol
4. customdried at 50-60° C.