Hydrochloric Acid → HCID 9933004, compound

HRID 2267200Notes

Reaction equation

HRID 2267200 reaction equation
[CH:1]1[C:6]([F:7])=[CH:5][C:4]2[CH2:8][CH2:9][CH:10]([CH:12]([OH:29])[CH2:13][NH:14][CH2:15][CH:16]([OH:28])[CH:17]3[O:26][C:25]4[CH:24]=[CH:23][C:22]([F:27])=[CH:21][C:20]=4[CH2:19][CH2:18]3)[O:11][C:3]=2[CH:2]=1.[ClH:30]>CO>[CH:23]1[C:22]([F:27])=[CH:21][C:20]2[CH2:19][CH2:18][CH:17]([CH:16]([OH:28])[CH2:15][NH:14][CH2:13][CH:12]([OH:29])[CH:10]3[O:11][C:3]4[CH:2]=[CH:1][C:6]([F:7])=[CH:5][C:4]=4[CH2:8][CH2:9]3)[O:26][C:25]=2[CH:24]=1.[ClH:30]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 71301Nebivolol

Product 1

HCID 9933004HCID 9933004, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Conditions

Temperature
5 °C

Procedure

The mixture of nebivolol (48.5 gm) and methanol (950 ml) was refluxed for 30 minutes and then subjected to carbon treatment. The resulting mass was cooled to 0-10° C., hydrochloric acid (6.5 ml) was slowly added during 30 minutes and then stirred for 4 hours at 0-10C. Filtered the material, washed with 50 ml of methanol and dried at 50-60° C. to give 27.5 gm of Nebivolol hydrochloride salt (HPLC purity: 99.5%).

Workup

  1. temperaturewas refluxed for 30 minutes
  2. filtrationFiltered the material
  3. washwashed with 50 ml of methanol
  4. customdried at 50-60° C.

Sources & evidence

ORD record
ord-fc8923023d8f4b74afe598df8921da99
Source dataset
uspto-grants-2010_12
Patent number
US07858812B2

Reaction notes

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