Hydrochloric Acid → HCID 66941891, compound

HRID 2267225Notes

Reaction equation

HRID 2267225 reaction equation
C([N:8]1[CH2:13][CH2:12][C:11]([N:15]2[CH2:20][CH2:19][N:18]([C:21]([O:23][C:24]([CH3:27])([CH3:26])[CH3:25])=[O:22])[CH2:17][CH2:16]2)([CH3:14])[CH2:10][CH2:9]1)C1C=CC=CC=1.[H][H].Cl>CO.[Pd]>[CH3:14][C:11]1([N:15]2[CH2:16][CH2:17][N:18]([C:21]([O:23][C:24]([CH3:27])([CH3:26])[CH3:25])=[O:22])[CH2:19][CH2:20]2)[CH2:12][CH2:13][NH:8][CH2:9][CH2:10]1

Participants

6

Reactant 3

HCID 313Hydrochloric AcidHCID 66942041HCID 66942041, compoundHCID 178418361HCID 178418361, compound2×

Product 1

HCID 66941891HCID 66941891, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

A suspension of 2.28 g (5.62 mmol) tert-butyl 4-(1-benzyl-4-methyl-piperidin-4-yl)-piperazine-1-carboxylate and 300 mg 10% Pd/C in 50 mL MeOH was hydrogenated for 3 h at 50° C. and 3447 hPa hydrogen pressure. To complete the reaction 0.47 mL conc. HCl were added and the mixture was hydrogenated for another 3 h at 50° C. and 3447 hPa hydrogen pressure. The catalyst was filtered off, the filtrate was evaporated down i. vac., the residue was stirred with diethyl ether, suction filtered and dried.

Workup

  1. additionwere added
  2. waitthe mixture was hydrogenated for another 3 h at 50° C.
  3. filtrationThe catalyst was filtered off
  4. customthe filtrate was evaporated down i
  5. filtrationfiltered
  6. customdried

Sources & evidence

ORD record
ord-60d4a6ca66b64ce88b2013f5a2372fc4
Source dataset
uspto-grants-2010_12
Patent number
US07858622B2

Reaction notes

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