Ethyl [4-(1-benzyl-4-methyl-piperidin-4-yl)-piperazin-1-yl]-acetate → Ethyl [4-(4-methyl-piperidin-4-yl)-piperazin-1-yl]acetate

HRID 2267227Notes

Reaction equation

HRID 2267227 reaction equation
[CH2:1]([O:3][C:4](=[O:26])[CH2:5][N:6]1[CH2:11][CH2:10][N:9]([C:12]2([CH3:25])[CH2:17][CH2:16][N:15](CC3C=CC=CC=3)[CH2:14][CH2:13]2)[CH2:8][CH2:7]1)[CH3:2].[H][H]>CCO.[Pd]>[CH2:1]([O:3][C:4](=[O:26])[CH2:5][N:6]1[CH2:11][CH2:10][N:9]([C:12]2([CH3:25])[CH2:17][CH2:16][NH:15][CH2:14][CH2:13]2)[CH2:8][CH2:7]1)[CH3:2]

Participants

5

Reactant 2

HCID 86650916Ethyl [4-(1-benzyl-4-methyl-piperidin-4-yl)-piperazin-1-yl]-acetateHCID 178418361HCID 178418361, compound

Product 1

HCID 57807651Ethyl [4-(4-methyl-piperidin-4-yl)-piperazin-1-yl]acetate

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

A suspension of 0.44 g (1.10 mmol) ethyl[4-(1-benzyl-4-methyl-piperidin-4-yl)-piperazin-1-yl]-acetate and 100 mg 10% Pd/C in 20 mL EtOH was hydrogenated for 12 h at 50° C. and 3447 hPa hydrogen pressure. The catalyst was filtered off and the filtrate was evaporated to dryness. The product was reacted further without purification.

Workup

  1. filtrationThe catalyst was filtered off
  2. customthe filtrate was evaporated to dryness
  3. customThe product was reacted further without purification

Sources & evidence

ORD record
ord-c5d5e8a07d43417fadb562b173def33c
Source dataset
uspto-grants-2010_12
Patent number
US07858622B2

Reaction notes

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