HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl [4-(1-benzyl-4-methyl-piperidin-4-yl)-piperazin-1-yl]-acetate → Ethyl [4-(4-methyl-piperidin-4-yl)-piperazin-1-yl]acetate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl [4-(1-benzyl-4-methyl-piperidin-4-yl)-piperazin-1-yl]-acetate | HCID 86650916 | — |
| Reactant | HCID 178418361 | HCID 178418361 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | Ethyl [4-(4-methyl-piperidin-4-yl)-piperazin-1-yl]acetate | HCID 57807651 | — |
Reaction Steps
A suspension of 0.44 g (1.10 mmol) ethyl[4-(1-benzyl-4-methyl-piperidin-4-yl)-piperazin-1-yl]-acetate and 100 mg 10% Pd/C in 20 mL EtOH was hydrogenated for 12 h at 50° C. and 3447 hPa hydrogen pressure. The catalyst was filtered off and the filtrate was evaporated to dryness. The product was reacted further without purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07858622B2 |
| Source dataset | uspto-grants-2010_12 |
| ORD ID | ord-c5d5e8a07d43417fadb562b173def33c |
| Source note | uspto-grants-2010_12 |