Lithium Hydroxide → HCID 57807462, compound

HRID 2267270Notes

Reaction equation

HRID 2267270 reaction equation
[O:1]=[C:2]1[N:8]([CH:9]2[CH2:14][CH2:13][N:12]([C:15]([O:17][C@H:18]([CH2:41][C:42]3[CH:47]=[C:46]([C:48]([F:51])([F:50])[F:49])[C:45]([NH2:52])=[C:44]([Cl:53])[CH:43]=3)[C:19]([N:21]3[CH2:26][CH2:25][N:24]([CH:27]4[CH2:32][CH2:31][N:30]([CH2:33][CH2:34][CH2:35][C:36]([O:38]CC)=[O:37])[CH2:29][CH2:28]4)[CH2:23][CH2:22]3)=[O:20])=[O:16])[CH2:11][CH2:10]2)[CH2:7][CH2:6][C:5]2[CH:54]=[CH:55][CH:56]=[CH:57][C:4]=2[NH:3]1.[Li+].[OH-]>>[O:1]=[C:2]1[N:8]([CH:9]2[CH2:10][CH2:11][N:12]([C:15]([O:17][C@H:18]([CH2:41][C:42]3[CH:47]=[C:46]([C:48]([F:50])([F:49])[F:51])[C:45]([NH2:52])=[C:44]([Cl:53])[CH:43]=3)[C:19]([N:21]3[CH2:22][CH2:23][N:24]([CH:27]4[CH2:32][CH2:31][N:30]([CH2:33][CH2:34][CH2:35][C:36]([OH:38])=[O:37])[CH2:29][CH2:28]4)[CH2:25][CH2:26]3)=[O:20])=[O:16])[CH2:13][CH2:14]2)[CH2:7][CH2:6][C:5]2[CH:54]=[CH:55][CH:56]=[CH:57][C:4]=2[NH:3]1

Participants

3

Reactant 2

HCID 3939Lithium HydroxideHCID 57807544HCID 57807544, compound

Product 1

HCID 57807462HCID 57807462, compound

Procedure

Prepared analogously to Example 27.1 from 50 mg (0.06 mmol) (R)-1-(4-amino-3-chloro-5-trifluoromethyl-benzyl)-2-{4-[1-(3-ethoxycarbonyl-propyl) -piperidin-4-yl]-piperazin-1-yl}-2-oxo-ethyl 4-(2-oxo-1,2,4,5-tetrahydro-1,3-benzodiazepin-3-yl)-piperidine-1-carboxylate and 2.40 mg (0.10 mmol) LiOH.

Sources & evidence

ORD record
ord-81e59d67f1e7432986a6de30a88a5b01
Source dataset
uspto-grants-2010_12
Patent number
US07858622B2

Reaction notes

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