Triethylamine → HCID 60204419, compound

HRID 2267331Notes

Reaction equation

HRID 2267331 reaction equation
CS([C:5]1[N:10]=[C:9]([C:11]2[S:15][C:14]([C:16]([N:18]3[CH2:23][CH2:22][O:21][CH2:20][CH2:19]3)=[O:17])=[CH:13][CH:12]=2)[CH:8]=[CH:7][N:6]=1)(=O)=O.[NH2:24][CH2:25][CH2:26][N:27]1[CH2:31][CH2:30][NH:29][C:28]1=[O:32].C(N(CC)CC)C>C1(C)C=CC=CC=1>[N:18]1([C:16]([C:14]2[S:15][C:11]([C:9]3[CH:8]=[CH:7][N:6]=[C:5]([NH:24][CH2:25][CH2:26][N:27]4[CH2:31][CH2:30][NH:29][C:28]4=[O:32])[N:10]=3)=[CH:12][CH:13]=2)=[O:17])[CH2:23][CH2:22][O:21][CH2:20][CH2:19]1

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 80480N-(2-Aminoethyl)ethyleneureaHCID 60204421HCID 60204421, compound

Product 1

HCID 60204419HCID 60204419, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

A mixture of (5-(2-(methylsulfonyl)pyrimidin-4-yl)thiophen-2-yl)(morpholino)methanone (100 mg, 0.26 mmol), 1-(2-aminoethyl)imidazolidin-2-one (36 mg, 0.28 mmol) and triethylamine (56 mg, 0.52 mmol) in toluene (3 mL) was refluxed for 6 h. After cooling to rt, the solvent was evaporated in vacuo and then methanol (5 mL) was added. After stirring for 15 min the solid was filtered and dried to give title compound as a light yellow solid. MS (M+H)+ 403.

Workup

  1. temperaturewas refluxed for 6 h
  2. customthe solvent was evaporated in vacuo
  3. additionmethanol (5 mL) was added
  4. filtrationwas filtered
  5. customdried

Sources & evidence

ORD record
ord-54288775190d4e8da0b3d5da1cc0ba5f
Source dataset
uspto-grants-2010_12
Patent number
US07858785B2

Reaction notes

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