1,2-Dichloroethane → 5-bromo-1H-indole-7-carboxamide

HRID 2267486Notes

Reaction equation

HRID 2267486 reaction equation
[Br:1][C:2]1[CH:3]=[C:4]2[C:8](=[C:9]([C:11]([OH:13])=O)[CH:10]=1)[NH:7][CH:6]=[CH:5]2.C(Cl)CCl.C1C=CC2N(O)N=[N:24]C=2C=1.N>C(Cl)Cl>[Br:1][C:2]1[CH:3]=[C:4]2[C:8](=[C:9]([C:11]([NH2:24])=[O:13])[CH:10]=1)[NH:7][CH:6]=[CH:5]2

Participants

6

Reactant 4

HCID 111,2-DichloroethaneHCID 222AmmoniaHCID 757711-HydroxybenzotriazoleHCID 533992575-Bromo-1H-indole-7-carboxylic acid

Product 1

HCID 596006575-bromo-1H-indole-7-carboxamideYield 99.6%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a solution of 5-bromo-1H-indole-7-carboxylic acid (10.0 g, 42 mmol) in CH2Cl2 (100 mL) at room temperature, EDC (9.66 g, 50.4 mmol), HOBt (6.81 g, 50.4 mmol) and NH3 (2.0 M in MeOH, 84 mL, 168 mmol) were added. The reaction mixture was stirred at room temperature for 16 hours. The solvent was evaporated and the residue partitioned between ethyl acetate (100 mL) and water (100 mL). The water layer was extracted with ethyl acetate (100 mL×2) and the combined organic phase was dried over MgSO4 and concentrated to give the crude product (10 g, 98%). This crude product was used directly in the next step without further purification.

Workup

  1. customThe solvent was evaporated
  2. customthe residue partitioned between ethyl acetate (100 mL) and water (100 mL)
  3. extractionThe water layer was extracted with ethyl acetate (100 mL×2)
  4. dry with materialthe combined organic phase was dried over MgSO4
  5. concentrationconcentrated

Sources & evidence

ORD record
ord-2c96a9e92af242faab81b45792fe40a7
Source dataset
uspto-grants-2010_12
Patent number
US07858796B2

Reaction notes

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