反应详情

To a solution of 1,1-dimethylethyl 4-[7-(aminocarbonyl)-5-(2-thienyl)-1H-indol-3-yl]-1-piperidinecarboxylate (90 mg, 0.22 mmol) in MeOH (3 mL), HCl (4.0M in dioxane, 2.06 mL) was added. The reaction mixture was stirred at ambient temperature for 2 hours, after which time the solvent was removed under reduced pressure and the resulting residue was partitioned between ethyl acetate (10 mL) and 10% sodium hydroxide (10 mL). The aqueous layer was extracted with ethyl acetate (10 mL×2) and the combined organic phase was dried over MgSO4 and concentrated to give a crude product (53 mg, 77%). This was used directly in the next step without further purification.

1. customafter which time the solvent was removed under reduced pressure
2. customthe resulting residue was partitioned between ethyl acetate (10 mL) and 10% sodium hydroxide (10 mL)
3. extractionThe aqueous layer was extracted with ethyl acetate (10 mL×2)
4. dry with materialthe combined organic phase was dried over MgSO4
5. concentrationconcentrated