反应详情

温度

0 °C

To a solution of 5-phenyl-3-(4-piperidinyl)-1H-indole-7-carboxamide (84.8 mg, 0.265 mmol) in CH2Cl2 at 0° C., triethylamine (0.15 mL, 1.06 mmol) and 2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)ethanesulfonyl chloride (87.03 mg, 0.32 mmol) were added. The reaction mixture was stirred at 0° C. for 30 min. The reaction mixture was partitioned between CH2Cl2 and water. The organic layer was separated and the aqueous layer was extracted with CH2Cl2 (2×). The combined organic phase washed with brine, dried over magnesium sulfate and filtered. The solvent was removed under reduced pressure to give the crude product (90 mg, 61%).

1. customThe reaction mixture was partitioned between CH2Cl2 and water
2. customThe organic layer was separated
3. extractionthe aqueous layer was extracted with CH2Cl2 (2×)
4. washThe combined organic phase washed with brine
5. dry with materialdried over magnesium sulfate
6. filtrationfiltered
7. customThe solvent was removed under reduced pressure