反应详情

To a solution of 1,1-dimethylethyl 4-[7-(aminocarbonyl)-5-(4-fluorophenyl)-1H-indol-3-yl]-1-piperidinecarboxylate (92.9 g, 0.205 mmol) in methanol (10 mL), HCl in dioxane (4M, 2.01 mL) was added. The reaction mixture was stirred at room temperature for 2 hours. The solvent was evaporated under reduced pressure and the resulting residue was partitioned between ethyl acetate (50 mL) and 5% of aqueous NaOH (50 mL). The aqueous layer washed with ethyl acetate (2×50 mL) and the combined organic phases were dried and concentrated under reduced pressure to give desired product (55.9 mg, 78%), which was used in the next step without further purification.

1. customThe solvent was evaporated under reduced pressure
2. customthe resulting residue was partitioned between ethyl acetate (50 mL) and 5% of aqueous NaOH (50 mL)
3. washThe aqueous layer washed with ethyl acetate (2×50 mL)
4. customthe combined organic phases were dried
5. concentrationconcentrated under reduced pressure