HRID2267501

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：NC(=O)c1cc(-c2cccc(CO)c2)cc2c(C3CCN(S(=O)(=O)CCCN4CCCC4)CC3)c[nH]c12

HCID11613367

5-[3-(hydroxymethyl)phenyl]-3-(1-{[3-(1-pyrrolidinyl)propyl]sulfonyl}-4-piperidinyl)-1H-indole-7-carboxamide

C28H36N4O4S

PRODUCTS

生成物

HCID59003333

未命名化合物

收率 60.2%

AUXILIARIES

试剂、催化剂与溶剂

催化剂HCID14801

Manganese oxide (Mn2O4)

MnO2

溶剂HCID8028

Tetrahydrofuran

C4H8O

PROCEDURE

实验过程

To a solution of 5-[3-(hydroxymethyl)phenyl]-3-(1-{[3-(1-pyrrolidinyl)propyl]sulfonyl}-4-piperidinyl)-1H-indole-7-carboxamide (250 mg, 0.477 mmol) in THF (60 mL) was added MnO2 (1.3 g, 14.30 mmol). The reaction mixture was stirred at room temperature overnight and filtered through a pad of celite after that. The filtrate was collected and concentrated at reduced pressure to give the crude product (150 mg, 60%), which was used in the next step without further purification.

WORKUP

后处理

filtrationfiltered through a pad of celite after that
customThe filtrate was collected
concentrationconcentrated at reduced pressure

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-77aa2e48a9804d97b174ef71ef09cc2c
来源数据集: uspto-grants-2010_12
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07858796B2
来源说明: uspto-grants-2010_12

反应 SMILES

[OH:1][CH2:2][C:3]1[CH:4]=[C:5]([C:9]2[CH:10]=[C:11]3[C:15](=[C:16]([C:18]([NH2:20])=[O:19])[CH:17]=2)[NH:14][CH:13]=[C:12]3[CH:21]2[CH2:26][CH2:25][N:24]([S:27]([CH2:30][CH2:31][CH2:32][N:33]3[CH2:37][CH2:36][CH2:35][CH2:34]3)(=[O:29])=[O:28])[CH2:23][CH2:22]2)[CH:6]=[CH:7][CH:8]=1>C1COCC1.O=[Mn]=O>[CH:2]([C:3]1[CH:4]=[C:5]([C:9]2[CH:10]=[C:11]3[C:15](=[C:16]([C:18]([NH2:20])=[O:19])[CH:17]=2)[NH:14][CH:13]=[C:12]3[CH:21]2[CH2:26][CH2:25][N:24]([S:27]([CH2:30][CH2:31][CH2:32][N:33]3[CH2:34][CH2:35][CH2:36][CH2:37]3)(=[O:29])=[O:28])[CH2:23][CH2:22]2)[CH:6]=[CH:7][CH:8]=1)=[O:1]