反应详情

The mixture of 3-{1-[(3-chloropropyl)sulfonyl]-4-piperidinyl}-5-phenyl-1H-indole-7-carboxamide (46.0 mg, 0.1 mmol), 0.1 M NaOMe (4 ml) in methanol (2 mL) was refluxed overnight. The reaction mixture was concentrated and purified by reverse phase HPLC (water/CH3CN, 0.1% TFA 10-90%) to give the title compound (20.0 mg, 44%).

1. temperaturewas refluxed overnight
2. concentrationThe reaction mixture was concentrated
3. custompurified by reverse phase HPLC (water/CH3CN, 0.1% TFA 10-90%)