HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Methoxide → 3-(1-{[3-(methyloxy)propyl]sulfonyl}-4-piperidinyl)-5-phenyl-1H-indole-7-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Methoxide | HCID 10942334 | — |
| Reactant | 3-{1-[(3-chloropropyl)sulfonyl]-4-piperidinyl}-5-phenyl-1H-indole-7-carboxamide | HCID 59003280 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 3-(1-{[3-(methyloxy)propyl]sulfonyl}-4-piperidinyl)-5-phenyl-1H-indole-7-carboxamide | HCID 59003356 | 44% |
Reaction Steps
The mixture of 3-{1-[(3-chloropropyl)sulfonyl]-4-piperidinyl}-5-phenyl-1H-indole-7-carboxamide (46.0 mg, 0.1 mmol), 0.1 M NaOMe (4 ml) in methanol (2 mL) was refluxed overnight. The reaction mixture was concentrated and purified by reverse phase HPLC (water/CH3CN, 0.1% TFA 10-90%) to give the title compound (20.0 mg, 44%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07858796B2 |
| Source dataset | uspto-grants-2010_12 |
| ORD ID | ord-343cad488e9e4b629b010dfe9530e4ee |
| Source note | uspto-grants-2010_12 |