HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2267572Generated: November 2, 2026
Potassium Carbonate → 3-[1-({3-[(methyloxy)amino]propyl}sulfonyl)-4-piperidinyl]-5-phenyl-1H-indole-7-carboxamide
https://huagongshe.com/reaction/2267572
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | O-Methylhydroxylamine hydrochloride | HCID 521874 | — |
| Reactant | 3-{1-[(3-chloropropyl)sulfonyl]-4-piperidinyl}-5-phenyl-1H-indole-7-carboxamide | HCID 59003280 | — |
| Catalyst | Sodium Iodide | HCID 5238 | — |
| Solvent | Dimethyl Sulfoxide | HCID 679 | — |
| Product | 3-[1-({3-[(methyloxy)amino]propyl}sulfonyl)-4-piperidinyl]-5-phenyl-1H-indole-7-carboxamide | HCID 59003358 | 50.6% |
Reaction Steps
The mixture of 3-{1-[(3-chloropropyl)sulfonyl]-4-piperidinyl}-5-phenyl-1H-indole-7-carboxamide (40.0 mg, 0.087 mmol) in DMSO (2.0 mL), were added O-methylhydroxylamine hydrochloride (83.5 mg, 1.0 mmol), K2CO3 (35.0 mg, 0.35 mmol) and sodium iodide (0.5 mg). The reaction solution was heated to 80° C. overnight. The reaction mixture was concentrated and purified by reverse phase HPLC (water/CH3CN, 0.1°/o TFA 10-90%) to give the title compound (20.7 mg, 43%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07858796B2 |
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| Source dataset | uspto-grants-2010_12 |
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| ORD ID | ord-b1037e570264453e881bd58c0147cfca |
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| Source note | uspto-grants-2010_12 |
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