反应详情

温度

80 °C

The mixture of 3-{1-[(3-chloropropyl)sulfonyl]-4-piperidinyl}-5-phenyl-1H-indole-7-carboxamide (40.0 mg, 0.087 mmol) in DMSO (2.0 mL), were added O-methylhydroxylamine hydrochloride (83.5 mg, 1.0 mmol), K2CO3 (35.0 mg, 0.35 mmol) and sodium iodide (0.5 mg). The reaction solution was heated to 80° C. overnight. The reaction mixture was concentrated and purified by reverse phase HPLC (water/CH3CN, 0.1°/o TFA 10-90%) to give the title compound (20.7 mg, 43%).

1. concentrationThe reaction mixture was concentrated
2. custompurified by reverse phase HPLC (water/CH3CN, 0.1°/o TFA 10-90%)