Triethylamine → HCID 59003289, compound

HRID 2267580Notes

Reaction equation

HRID 2267580 reaction equation
[C:1]1([C:7]2[CH:8]=[C:9]3[C:13](=[C:14]([C:16]([NH2:18])=[O:17])[CH:15]=2)[NH:12][CH:11]=[C:10]3[CH:19]2[CH2:24][CH2:23][NH:22][CH2:21][CH2:20]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[C:25]1([CH2:31][NH:32][CH2:33][C:34]2[S:38][C:37]([S:39](Cl)(=[O:41])=[O:40])=[CH:36][CH:35]=2)[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=1.C(N(CC)CC)C>>[C:1]1([C:7]2[CH:8]=[C:9]3[C:13](=[C:14]([C:16]([NH2:18])=[O:17])[CH:15]=2)[NH:12][CH:11]=[C:10]3[CH:19]2[CH2:24][CH2:23][N:22]([S:39]([C:37]3[S:38][C:34]([CH2:33][NH:32][CH2:31][C:25]4[CH:26]=[CH:27][CH:28]=[CH:29][CH:30]=4)=[CH:35][CH:36]=3)(=[O:40])=[O:41])[CH2:21][CH2:20]2)[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

Participants

4

Reactant 3

HCID 8471TriethylamineHCID 114271625-Phenyl-3-(4-piperidinyl)-1H-indole-7-carboxamideHCID 86232192HCID 86232192, compound

Product 1

HCID 59003289HCID 59003289, compound

Procedure

Following the general procedure in example 267, 5-(phenyl)-3-(4-piperidinyl)-1H-indole-7-carboxamide (32 mg, 0.1 mmol), 5-{[(phenylmethyl)amino]methyl}-2-thiophenesulfonyl chloride (45.3 mg, 0.15 mmol) and triethylamine (0.06 mL, 0.3 mmol) were reacted to form the desired product which was purified by Gilson HPLC (CH3CN/Water, 0.1% TFA) (20 mg, 34%).

Workup

  1. customwere reacted

Sources & evidence

ORD record
ord-2c3185ee004846bdada63f62e9864932
Source dataset
uspto-grants-2010_12
Patent number
US07858796B2

Reaction notes

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