反应详情

To 5-(5-formyl-3-thienyl)-3-(1-{[3-(methyloxy)propyl]sulfonyl}-4-piperidinyl)-1H-indole-7-carboxamide (40 mg, 0.08 mmol) in a mixture of dichloromethane (1.25 mL) and methanol (0.5 mL), pyrrolidine (0.07 mL, 0.8 mmol) and 2 drops of acetic acid were added. After the reaction mixture was stirred at room temperature for 6 hours, NaBH4 (30.26 mg, 0.8 mmol) was added. Then the reaction mixture was stirred at room temperature for 30 minutes. All the solvent was evaporated and purified by Gilson HPLC (CH3CN/Water, 0.1% TFA) to give title compound (6.5 mg, 15%).

1. additionwere added
2. stirringThen the reaction mixture was stirred at room temperature for 30 minutes
3. customAll the solvent was evaporated
4. custompurified by Gilson HPLC (CH3CN/Water, 0.1% TFA)