HuagongsheHuagongshe Chemistry Print Report · For research reference only
Tert-Butylamine → 5-(5-{[(1,1-dimethylethyl)amino]methyl}-3-thienyl)-3-(1-{[3-(methyloxy)propyl]sulfonyl}-4-piperidinyl)-1H-indole-7-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Tert-Butylamine | HCID 6385 | — |
| Reactant | Sodium borohydride | HCID 4311764 | — |
| Reactant | 5-(5-formyl-3-thienyl)-3-(1-{[3-(methyloxy)propyl]sulfonyl}-4-piperidinyl)-1H-indole-7-carboxamide | HCID 11620105 | — |
| Product | 5-(5-{[(1,1-dimethylethyl)amino]methyl}-3-thienyl)-3-(1-{[3-(methyloxy)propyl]sulfonyl}-4-piperidinyl)-1H-indole-7-carboxamide | HCID 59003303 | — |
Reaction Steps
Following the general procedure in example 281, 5-(5-formyl-3-thienyl)-3-(1-{[3-(methyloxy)propyl]sulfonyl}-4-piperidinyl)-1H-indole-7-carboxamide (40 mg, 0.08 mmol), (1,1-dimethylethyl)amine (70 mg, 0.8 mmol) and NaBH4 (30.26 mg, 0.8 mmol) were reacted to form the desired product which was purified by Gilson HPLC (CH3CN/Water, 0.1% TFA) (8.4 mg, 19%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07858796B2 |
| Source dataset | uspto-grants-2010_12 |
| ORD ID | ord-505aa8c8663747f6b58a09a69ceb66ef |
| Source note | uspto-grants-2010_12 |