HRID2267591

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID6385

tert-Butylamine

C4H11N

HCID4311764

Sodium borohydride (Na(BH4))

H4BNa

结构：COCCCS(=O)(=O)N1CCC(c2c[nH]c3c(C(N)=O)cc(-c4csc(C=O)c4)cc23)CC1

HCID11620105

未命名化合物

PRODUCTS

生成物

结构：COCCCS(=O)(=O)N1CCC(c2c[nH]c3c(C(N)=O)cc(-c4csc(CNC(C)(C)C)c4)cc23)CC1

HCID59003303

未命名化合物

PROCEDURE

实验过程

Following the general procedure in example 281, 5-(5-formyl-3-thienyl)-3-(1-{[3-(methyloxy)propyl]sulfonyl}-4-piperidinyl)-1H-indole-7-carboxamide (40 mg, 0.08 mmol), (1,1-dimethylethyl)amine (70 mg, 0.8 mmol) and NaBH4 (30.26 mg, 0.8 mmol) were reacted to form the desired product which was purified by Gilson HPLC (CH3CN/Water, 0.1% TFA) (8.4 mg, 19%).

WORKUP

后处理

customwere reacted

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-505aa8c8663747f6b58a09a69ceb66ef
来源数据集: uspto-grants-2010_12
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07858796B2
来源说明: uspto-grants-2010_12

反应 SMILES

[CH:1]([C:3]1[S:7][CH:6]=[C:5]([C:8]2[CH:9]=[C:10]3[C:14](=[C:15]([C:17]([NH2:19])=[O:18])[CH:16]=2)[NH:13][CH:12]=[C:11]3[CH:20]2[CH2:25][CH2:24][N:23]([S:26]([CH2:29][CH2:30][CH2:31][O:32][CH3:33])(=[O:28])=[O:27])[CH2:22][CH2:21]2)[CH:4]=1)=O.[CH3:34][C:35]([NH2:38])([CH3:37])[CH3:36].[BH4-].[Na+]>>[CH3:34][C:35]([NH:38][CH2:1][C:3]1[S:7][CH:6]=[C:5]([C:8]2[CH:9]=[C:10]3[C:14](=[C:15]([C:17]([NH2:19])=[O:18])[CH:16]=2)[NH:13][CH:12]=[C:11]3[CH:20]2[CH2:21][CH2:22][N:23]([S:26]([CH2:29][CH2:30][CH2:31][O:32][CH3:33])(=[O:27])=[O:28])[CH2:24][CH2:25]2)[CH:4]=1)([CH3:37])[CH3:36]