HCID 68605009, compound → HCID 68606635, compound

HRID 2267666Notes

Reaction equation

HRID 2267666 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([CH2:9][C:10]([NH:12][C@H:13]([C:17]([O:19][CH3:20])=[O:18])[CH:14](C)[CH3:15])=[O:11])[CH:5]=[C:6]([F:8])[CH:7]=1.Cl.CN[C@H](C(O)=O)C[CH2:26][S:27]C>>[F:1][C:2]1[CH:3]=[C:4]([CH2:9][C:10]([NH:12][C@H:13]([C:17]([O:19][CH3:20])=[O:18])[CH2:14][CH2:15][S:27][CH3:26])=[O:11])[CH:5]=[C:6]([F:8])[CH:7]=1

Participants

3

Reactant 2

HCID 68605009HCID 68605009, compoundHCID 86619279HCID 86619279, compound

Product 1

HCID 68606635HCID 68606635, compound

Procedure

A method similar to that used for the preparation of (107a) was used except that methyl-L-methionine hydrochloride (214 mg) was used instead of methyl-L-valinate hydrochloride to afford the desired product (300 mg). 1H NMR (300 MHz, CDCl3) δ 1.178 (t, 3H, J=7 Hz), 1.93 (m, 2H), 2.02 (s, 3H), 2.51 (m, 2H), 3.53 (s, 2H), 4.38 (m, 1H), 7.07 (m, 3H), 8.54 (d, 1H, J=8 Hz). LC/MS: 2.28 min.

Sources & evidence

ORD record
ord-0de07464356b4642b3c53976a775e689
Source dataset
uspto-grants-2010_12
Patent number
US07858776B2

Reaction notes

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