HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 1-[2-(4-Methyl-piperidin-1-yl)-ethyl]-piperidin-4-ylamine tri-hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Dichloromethane | HCID 6344 | — |
| Reactant | {1-[2-(4-Methyl-piperidin-1-yl)-ethyl]-piperidin-4-yl}-carbamic acid tert-butyl ester | HCID 66841138 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | 1-[2-(4-Methyl-piperidin-1-yl)-ethyl]-piperidin-4-ylamine tri-hydrochloride | HCID 66841322 | — |
Reaction Steps
The tert-butyl ester 9 (2 g, 6.14 mmol) is suspended in 10 ml of dioxane. DCM is then added until the solid dissolved. To this mixture, 4M-HCl in dioxane (12.3 ml, 49.2 mmol) is added. After stirring over night the solvents are evaporated to leave a white solid product.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07858781B2 |
| Source dataset | uspto-grants-2010_12 |
| ORD ID | ord-d194688df06a48d293b404820760e411 |
| Source note | uspto-grants-2010_12 |