Hydrochloric Acid → 1-[2-(4-Methyl-piperidin-1-yl)-ethyl]-piperidin-4-ylamine tri-hydrochloride

HRID 2267680Notes

Reaction equation

HRID 2267680 reaction equation
C(OC(=O)[NH:7][CH:8]1[CH2:13][CH2:12][N:11]([CH2:14][CH2:15][N:16]2[CH2:21][CH2:20][CH:19]([CH3:22])[CH2:18][CH2:17]2)[CH2:10][CH2:9]1)(C)(C)C.C(Cl)[Cl:25].[ClH:27]>O1CCOCC1>[ClH:25].[ClH:27].[ClH:25].[CH3:22][CH:19]1[CH2:18][CH2:17][N:16]([CH2:15][CH2:14][N:11]2[CH2:10][CH2:9][CH:8]([NH2:7])[CH2:13][CH2:12]2)[CH2:21][CH2:20]1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 6344DichloromethaneHCID 66841138{1-[2-(4-Methyl-piperidin-1-yl)-ethyl]-piperidin-4-yl}-carbamic acid tert-butyl ester

Product 1

HCID 668413221-[2-(4-Methyl-piperidin-1-yl)-ethyl]-piperidin-4-ylamine tri-hydrochloride

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent2×

Procedure

The tert-butyl ester 9 (2 g, 6.14 mmol) is suspended in 10 ml of dioxane. DCM is then added until the solid dissolved. To this mixture, 4M-HCl in dioxane (12.3 ml, 49.2 mmol) is added. After stirring over night the solvents are evaporated to leave a white solid product.

Workup

  1. dissolutiondissolved
  2. customare evaporated
  3. customto leave a white solid product

Sources & evidence

ORD record
ord-d194688df06a48d293b404820760e411
Source dataset
uspto-grants-2010_12
Patent number
US07858781B2

Reaction notes

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