Hydrochloric Acid → (3S,4S)-1-[2-(4-Amino-piperidin-1-yl)-ethyl]-3-methyl-piperidin-4-ol trihydrochloride

HRID 2267686Notes

Reaction equation

HRID 2267686 reaction equation
C(OC(=O)[NH:7][CH:8]1[CH2:13][CH2:12][N:11]([CH2:14][CH2:15][N:16]2[CH2:21][CH2:20][C@H:19]([OH:22])[C@@H:18]([CH3:23])[CH2:17]2)[CH2:10][CH2:9]1)(C)(C)C.[ClH:25].O1CCOCC1.Cl.Cl.Cl.CC1CCN(CCN2CCC(N)CC2)CC1>>[ClH:25].[ClH:25].[ClH:25].[NH2:7][CH:8]1[CH2:13][CH2:12][N:11]([CH2:14][CH2:15][N:16]2[CH2:21][CH2:20][C@H:19]([OH:22])[C@@H:18]([CH3:23])[CH2:17]2)[CH2:10][CH2:9]1

Participants

5

Reactant 4

HCID 313Hydrochloric AcidHCID 312751,4-DioxaneHCID 668413221-[2-(4-Methyl-piperidin-1-yl)-ethyl]-piperidin-4-ylamine tri-hydrochlorideHCID 67523806{1-[2-((3S,4S)-4-Hydroxy-3-methyl-piperidin-1-yl)-ethyl]-piperidin-4-yl}-carbamic acid tert-butyl ester

Product 1

HCID 66841748(3S,4S)-1-[2-(4-Amino-piperidin-1-yl)-ethyl]-3-methyl-piperidin-4-ol trihydrochloride

Procedure

It is prepared by BOC-cleavage of tert-butyl ester 16 (3.07 g, 8.98 mmol) with 4M-HCl in dioxane (11.2 ml, 44.8 mmol) as described for amine 7.

Sources & evidence

ORD record
ord-f7ae9f3f42574fb2bfec731c2a3ad4e2
Source dataset
uspto-grants-2010_12
Patent number
US07858781B2

Reaction notes

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