HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → (3R,4R)-3-methylpiperidin-4-yl pivalate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | trans-2,2-Dimethyl-propionic acid 1-benzyl-3-methyl-piperidin-4-yl ester | HCID 131728602 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | (3R,4R)-3-methylpiperidin-4-yl pivalate | HCID 59600263 | — |
Reaction Steps
The trans-ester 18 (104 g, 359 mmol) is hydrogenated in methanol (1700 ml) with Pd/C in the presence of one equivalent of HCl (431 ml, 359 mmol, 1.25M in MeOH). The mixture is filtered and evaporated. The residue is redissolved in ether and extracted with 1N—NaOH and brine. Evaporation gives a colourless oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07858781B2 |
| Source dataset | uspto-grants-2010_12 |
| ORD ID | ord-7a4687c3c03e4e63924ddf9a5848a518 |
| Source note | uspto-grants-2010_12 |