HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → Piperidin-4-yl pivalate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 2,2-Dimethyl-propionic acid 1-benzyl-piperidin-4-yl ester | HCID 66841565 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | Piperidin-4-yl pivalate | HCID 57464983 | — |
Reaction Steps
A solution of piperidine 51 (35.99 g, 130.7 mmol) in methanol is hydrogenated with Pd/C in the presence of one equivalent of HCl (104.5 ml, 130.7 mmol, 1.25M in MeOH). After filtration and evaporation, the crude is taken up in ether and washed with 1N—NaOH and brine. Drying, evaporation and distillation (0.08 mbar, 75-90 C) gave a colourless oil. Yield: 17.98 g (74%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07858781B2 |
| Source dataset | uspto-grants-2010_12 |
| ORD ID | ord-6331622090a44f008539bbb5c8ccca71 |
| Source note | uspto-grants-2010_12 |