Hydrochloric Acid → HCID 66841433, compound

HRID 2267709Notes

Reaction equation

HRID 2267709 reaction equation
C(OC(=O)[NH:7][CH:8]1[CH2:13][CH2:12][N:11]([CH2:14][C@@H:15]([N:17]2[CH2:22][CH2:21][CH:20]([OH:23])[CH2:19][CH2:18]2)[CH3:16])[CH2:10][CH2:9]1)(C)(C)C.[ClH:25].O1CCOCC1.Cl.Cl.Cl.CC1CCN(CCN2CCC(N)CC2)CC1>>[ClH:25].[ClH:25].[ClH:25].[NH2:7][CH:8]1[CH2:9][CH2:10][N:11]([CH2:14][C@@H:15]([N:17]2[CH2:18][CH2:19][CH:20]([OH:23])[CH2:21][CH2:22]2)[CH3:16])[CH2:12][CH2:13]1

Participants

5

Reactant 4

HCID 313Hydrochloric AcidHCID 312751,4-DioxaneHCID 668413221-[2-(4-Methyl-piperidin-1-yl)-ethyl]-piperidin-4-ylamine tri-hydrochlorideHCID 66841883HCID 66841883, compound

Product 1

HCID 66841433HCID 66841433, compound

Procedure

It is prepared by BOC-cleavage of tert-butyl ester 55 (0.666 g, 1.95 mmol) with 4M-HCl in dioxane (2.93 ml, 11.72 mmol) as described for amine 7.

Sources & evidence

ORD record
ord-343e59805adc4b45b597e9ecf54dae67
Source dataset
uspto-grants-2010_12
Patent number
US07858781B2

Reaction notes

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